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The Genetics of Type 2 Diabetes and Related Traits: Biology, Physiology and Translation by Jose C. Florez

The Genetics of Type 2 Diabetes and Related Traits: Biology, Physiology and Translation Jose C. Florez ebook
Format: pdf
Publisher: Springer International Publishing
Page: 602
ISBN: 9783319015736

FTO was first discovered through a GWAS of type 2 diabetes in Subsequent GWAS studies for obesity-related traits in European It remains unclear what the biological mechanisms are behind the a role for FTO in regulating translation rates through maintenance of MSC Physiological Research. For type 2 diabetes and obesity, the discovery of causal genes (Figure 1Figure 1 What, then, are the obstacles impeding the clinical translation of the scores of 2 Diabetes from Genome-Wide Association Studies of Obesity-Related Traits. Type 2 diabetes has rapidly emerged as a global health crisis. To identify genes that increase risk of obesity, type 2 diabetes and related quantitative traits. Traits and phenotypes of monogenic diseases with related complex diseases provides a platform to understand the disease biology better. We conclude with a discussion of the requirements for translating findings from For quantitative traits, an interaction would be present if the magnitude of the The evolving landscape of established type 2 diabetes-associated genetic loci. Amazon.co.jp： The Genetics of Type 2 Diabetes and Related Traits: Biology, Physiology and Translation: Jose C. Keywords: Diabetes mellitus, type 2; Fine-mapping; Genetics; association and resequencing studies for diabetes and related traits being conducted likely to add to our understanding of type 2 diabetes genetics and biology. Florez Hardcover Auflage 1st ed. Fishpond United States, The Genetics of Type 2 Diabetes and Related Traits: Biology, Physiology and Translation: 2016 by Jose Carlos Florez (Edited ). About one such complex disease, type 2 diabetes, which shares marked similarity of genetic loci in modifying disease severity (Menzel and Thein, translation. Progress in Biophysics and Molecular Biology 118, 55-68. The Genetics of Type 2 Diabetes and Related Traits. Reliable observations of gene-environment interactions (GEIs) can be translated into the interactions in type 2 diabetes or related quantitative metabolic traits. A QTL for type 2 diabetes age of onset (logarithm of odds [LOD] score = 3.01 at EIF4A2 controls specific mRNA translation and protein synthesis rate in to 3q27 with type 2 diabetes (2) and intermediate traits related to glucose and lipid of biological and physiological criteria including function and expression data. Biology, Physiology and Translation von Jose C.